Fuchs S, Yaffe R, Beeri R, Rosen S, Heyman S N, Brezis M
Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Exp Nephrol. 1997 Jan-Feb;5(1):88-94.
Exogenous insulin-like growth factor 1 (IGF-1) has been reported to improve experimental ischemic acute renal failure. We investigated a possible beneficial role of IGF-1 in a model of radiocontrast nephropathy induced by indomethacin, nitro-L-arginine ester and iothalamate. Multiple injections of recombinant human IGF-1 (or its vehicle) at 150 microg/100 g body weight/day were given for 24 h starting 1 h after radiocontrast, or initiated 1 day after the insults and continued for 48 h. IGF-1 prevented neither the fall in creatinine clearance nor medullary thick ascending limb necrosis observed at 24 h. Similarly IGF-1, given for 2 days after renal failure had been established, did not accelerate functional recovery at 72 h, did not ameliorate catabolism and did not alter the morphological evolution of intrarenal damage. In conclusion, IGF-1 had no beneficial effects in this model of radiocontrast nephropathy.
据报道，外源性胰岛素样生长因子1（IGF-1）可改善实验性缺血性急性肾衰竭。我们研究了IGF-1在由吲哚美辛、硝基-L-精氨酸酯和碘他拉酸盐诱导的放射性造影剂肾病模型中的可能有益作用。在给予放射性造影剂1小时后开始，以150μg/100g体重/天的剂量多次注射重组人IGF-1（或其载体），持续24小时，或在损伤后1天开始并持续48小时。IGF-1既不能防止24小时时观察到的肌酐清除率下降，也不能防止髓袢升支粗段坏死。同样，在肾衰竭确立后给予2天的IGF-1，在72小时时并未加速功能恢复，未改善分解代谢，也未改变肾内损伤的形态演变。总之，在该放射性造影剂肾病模型中，IGF-1没有有益作用。
