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[雷诺所描述的临床症状是对应一种疾病实体还是一种具有多种病因的综合征?]

[Do the clinical symptoms described by Raynaud correspond to a nosological entity or a syndrome with multiple etiologies?].

作者信息

Kluken N

出版信息

Phlebologie. 1977 Apr-Jun;30(2):185-8.

PMID:905341
Abstract

In considering this problem, our opinion concerning Raynaud's phenomenon is as follows: The symptomatology described by Raynaud includes among other things a local asphyxia and gangrene. All the patients in whom these two signs are not found should not therefore be included under the label of Raynaud's disease. It is preferable in such cases to use Reil's term of "dead fingers". But our experience shows that if there is local asphyxia or even gangrene, in addition to the syncopal episodes, there is always a causal disease. However it is not justifiable here to speak of Raynaud's disease, but rather of Raynaud's syndrome or Raynaud's phenomenon complicating some causal disorder, such as progressive scleroderma or obstructive arterial disease with digital localisation. The phenomenon of "dead fingers" is very common and most marked at the time of puberty. The symptoms regress in the years following. It is rare to see Raynaud's phenomenon at the time of puberty, this being commoner in later decades, with a course which is more or less pronounced and progressive according to the underlying disease. The prognosis is also a function of the underlying disease and is likely to be unfavourable, even threatening life, in cases of progressive scleroderma.

摘要

在考虑这个问题时,我们对雷诺现象的看法如下:雷诺所描述的症状包括局部缺血和坏疽等。因此,所有未发现这两种体征的患者不应被归为雷诺病。在这种情况下,最好使用赖尔所说的“死指”一词。但我们的经验表明,如果除了晕厥发作外还存在局部缺血甚至坏疽,那么总是存在一种病因性疾病。然而,这里说雷诺病是不合理的,而应说是雷诺综合征或雷诺现象并发某些病因性疾病,如进行性硬皮病或指部局限性阻塞性动脉疾病。“死指”现象非常常见,在青春期最为明显。症状在随后几年会消退。青春期出现雷诺现象很少见,这种情况在随后几十年更常见,其病程根据潜在疾病或多或少会明显且呈进行性发展。预后也取决于潜在疾病,在进行性硬皮病的情况下可能预后不良,甚至危及生命。

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