Yokota S, Kuriyama T, Takahashi Y, Mori M, Shike H, Ibe M, Mitsuda T, Aihara Y
Department of Pediatrics, Yokohama City University School of Medicine.
Ryumachi. 1994 Dec;34(6):955-60.
To assess Raynaud's phenomenon objectively, thermographic estimation of hands and fingers was performed before and after the disease- and Raynaud's phenomenon-directed therapy in 3 children with mixed connective tissue disease. All the cases were positive in Raynaud's phenomenon, and the surface temperature of their hands and fingers were decreased even before cold challenge. After the cold provocation test at 4 degrees C for 10 sec., the temperature of all or some of the fingers were rapidly decreased, and the recovery of surface temperature of these fingers were markedly delayed. Even after methylprednisolone pulse therapy the pattern of the finger temperature were essentially unchanged, suggesting that steroids are not effective in the treatment of Raynaud's phenomenon. The long-term administration of vitamin-E, oral prostaglandin E1, and/or serotonin-receptor inhibitor were also proved to be not beneficial in improving Raynaud's phenomenon. Thus, thermography is useful in diagnosing Raynaud's phenomenon objectively, in determining the efficacy of anti-Raynaud drugs, and in estimating long-term course of the phenomenon.
为了客观评估雷诺现象，对3例混合性结缔组织病患儿在疾病及针对雷诺现象的治疗前后进行了手部和手指的热成像评估。所有病例的雷诺现象均呈阳性，甚至在冷刺激前其手部和手指的表面温度就已降低。在4℃下进行10秒的冷激发试验后，所有或部分手指的温度迅速下降，且这些手指表面温度的恢复明显延迟。即使在甲泼尼龙冲击治疗后，手指温度模式基本未变，这表明类固醇对雷诺现象的治疗无效。长期服用维生素E、口服前列腺素E1和/或血清素受体抑制剂也被证明对改善雷诺现象无益。因此，热成像在客观诊断雷诺现象、确定抗雷诺药物的疗效以及评估该现象的长期病程方面很有用。
