Berger J W, D'Amico D J
Laser Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA.
Ophthalmic Surg Lasers. 1997 Feb;28(2):133-9.
Motivated by the potential for highly precise tissue removal, investigators are exploring fiberoptic microsurgical maneuvers with the erbium:YAG (Er:YAG) laser. Tissue is disrupted and removed by direct ablation and the acousto-mechanical sequelae of explosive vaporization of the tissue water. The authors investigated the scaling laws for photoablative and photodisruptive interactions and interpreted these results to optimize energy delivery for vitreoretinal surgical maneuvers.
A model for laser-generated-bubble expansion is presented based on energy principles and adiabatic gas expansion. Comparisons are made with the authors' previous studies of ablation rate and thermometry.
The authors' modeling studies generated predictions similar to experimental data. The maximum bubble diameter increases as the cube root of the pulse energy. At constant radiant exposure, the maximum bubble diameter increases as the probe tip diameter raised to the two-thirds power. The authors demonstrated that tissue ablation depends on radiant exposure (J/cm2), whereas temperature increases, bubble size, and peak pressure depend on total pulse energy.
Mechanical injury should be minimized and efficient ablation preserved by delivering low-pulse energy through small-diameter probe tips at high repetition rates.
受高精度组织切除潜力的驱动,研究人员正在探索使用铒:钇铝石榴石(Er:YAG)激光进行光纤显微手术操作。组织通过直接消融以及组织水爆炸性汽化的声机械后遗症而被破坏和切除。作者研究了光消融和光破坏相互作用的比例定律,并对这些结果进行解释,以优化玻璃体视网膜手术操作的能量传递。
基于能量原理和绝热气体膨胀提出了激光产生气泡膨胀的模型。并与作者之前关于消融率和温度测量的研究进行了比较。
作者的建模研究得出的预测结果与实验数据相似。最大气泡直径随脉冲能量的立方根增加。在恒定辐射暴露下,最大气泡直径随探针尖端直径的三分之二次幂增加。作者证明组织消融取决于辐射暴露(焦耳/平方厘米),而温度升高、气泡大小和峰值压力取决于总脉冲能量。
通过以高重复率通过小直径探针尖端传递低脉冲能量,应将机械损伤降至最低并保持有效的消融。