Wong T Y, Au Eong K G, Chan W K, Tseng P S
Department of Ophthalmology, Tan Tock Seng Hospital, Singapore.
Ann Acad Med Singap. 1996 Nov;25(6):862-5.
Keratomycosis is a rare sight-threatening infection of the cornea. Important predisposing factors in its pathogenesis include corneal trauma and use of topical corticosteroid or antibiotic-corticosteroid therapy. Some family physicians are unaware of the dangers of unmonitored topical corticosteroid therapy for traumatised eyes. Three cases of Fusarium keratitis following the use of topical antibiotic-corticosteroid therapy in traumatised eyes are reported. Despite aggressive anti-fungal therapy, one eye required a therapeutic penetrating keratoplasty for impending corneal perforation, another eye progressed to corneal perforation and required evisceration while the third eye developed endophthalmitis which also required evisceration. The potential danger of fungal infections of the cornea following the unmonitored use of topical antibiotic-corticosteroids in traumatised eyes is highlighted.
角膜真菌病是一种罕见的可威胁视力的角膜感染。其发病机制中的重要诱发因素包括角膜外伤以及局部使用皮质类固醇或抗生素 - 皮质类固醇疗法。一些家庭医生并未意识到未受监测的局部皮质类固醇疗法对受伤眼睛的危险性。本文报告了3例因在受伤眼睛使用局部抗生素 - 皮质类固醇疗法后发生镰刀菌角膜炎的病例。尽管进行了积极的抗真菌治疗，但一只眼睛因即将发生角膜穿孔而需要进行治疗性穿透性角膜移植术，另一只眼睛发展为角膜穿孔并需要进行眼球摘除术，而第三只眼睛发生了眼内炎，同样需要进行眼球摘除术。强调了在受伤眼睛中未受监测地使用局部抗生素 - 皮质类固醇后角膜真菌感染的潜在危险。
