Wong T Y, Fong K S, Tan D T
Singapore National Eye Center, Singapore.
Int Ophthalmol. 1997;21(3):127-30. doi: 10.1023/a:1026462631716.
The epidemiology of fungal keratitis varies geographically, but commonly occurs in warm, tropical climates. To determine the microbial and clinical characteristics of this disease in Singapore, we conducted a 5-year hospital-based retrospective study.
A retrospective review of culture-positive fungal keratitis at the Singapore National Eye Center and Singapore General Hospital, from January 1991 to December 1995.
Twenty-nine consecutive cases of culture-positive fungal keratitis were seen over the study period. The mean age of the cases was 41 years and 23 were males. Amongst the varied occupations, 9 were construction workers. The most common cultured organisms were Fusarium sp. (52%) and Aspergillus flavus (17%). More than half had a history of ocular trauma prior to the development of keratitis, while a quarter had antecedent topical corticosteroid therapy. In contrast, only 2 patients were contact-lens wearers. Despite medical therapy, 10 patients eventually required therapeutic penetrating keratoplasties; of these, 6 were caused by Fusarium species.
Fusarium is the commonest cultured organism in fungal keratitis in Singapore and is associated with significant ocular morbidity.
真菌性角膜炎的流行病学情况因地域而异，但常见于温暖的热带气候地区。为确定新加坡该疾病的微生物学和临床特征，我们开展了一项为期5年的基于医院的回顾性研究。
回顾性分析1991年1月至1995年12月期间新加坡国立眼科中心和新加坡总医院培养阳性的真菌性角膜炎病例。
在研究期间共观察到29例连续的培养阳性真菌性角膜炎病例。病例的平均年龄为41岁，男性23例。在不同职业中，9例为建筑工人。最常见的培养菌为镰刀菌属（52%）和黄曲霉（17%）。超过一半的患者在角膜炎发病前有眼外伤史，四分之一有局部皮质类固醇治疗史。相比之下，只有2例患者为隐形眼镜佩戴者。尽管进行了药物治疗，10例患者最终仍需要治疗性穿透性角膜移植术；其中6例由镰刀菌属引起。
镰刀菌是新加坡真菌性角膜炎最常见的培养菌，且与严重的眼部发病率相关。
