角膜溃疡继发镰刀菌性眼内炎的成功挽救治疗：一项介入性病例系列研究
Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series.
作者信息
Comer Grant M, Stem Maxwell S, Saxe Stephen J
机构信息
University of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA.
出版信息
Clin Ophthalmol. 2012;6:721-6. doi: 10.2147/OPTH.S31652. Epub 2012 May 9.
PURPOSE
To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis.
DESIGN
Interventional case series.
PARTICIPANTS
Three consecutive patients with keratitis-associated Fusarium endophthalmitis.
METHODS
After failure of traditional management options, a combination of intravitreal and long-term, high-dose systemic voriconazole, topical antifungal medications, and surgical intervention, with penetrating keratoplasty, lensectomy, and endoscopic-guided pars plana vitrectomy, was administered to each patient.
RESULTS
All three cases achieved full resolution of the infection, with a final Snellen visual acuity score of 20/50 to 20/70.
CONCLUSIONS
An aggressive combination of therapeutic modalities, including the removal of subiris abscesses, might be needed for the successful resolution of Fusarium endophthalmitis.
目的
描述用于成功根除镰刀菌性眼内炎的多种治疗方式的联合应用。
设计
干预性病例系列。
参与者
3例连续性角膜相关镰刀菌性眼内炎患者。
方法
在传统治疗方法失败后，对每位患者采用玻璃体内及长期大剂量全身伏立康唑、局部抗真菌药物以及手术干预的联合治疗，包括穿透性角膜移植术、晶状体切除术和内镜引导下经平坦部玻璃体切除术。
结果
所有3例感染均完全消退，最终Snellen视力评分为20/50至20/70。
结论
对于成功解决镰刀菌性眼内炎，可能需要积极联合多种治疗方式，包括清除虹膜下脓肿。
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