Comer Grant M, Stem Maxwell S, Saxe Stephen J
University of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA.
Clin Ophthalmol. 2012;6:721-6. doi: 10.2147/OPTH.S31652. Epub 2012 May 9.
To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis.
Interventional case series.
Three consecutive patients with keratitis-associated Fusarium endophthalmitis.
After failure of traditional management options, a combination of intravitreal and long-term, high-dose systemic voriconazole, topical antifungal medications, and surgical intervention, with penetrating keratoplasty, lensectomy, and endoscopic-guided pars plana vitrectomy, was administered to each patient.
All three cases achieved full resolution of the infection, with a final Snellen visual acuity score of 20/50 to 20/70.
An aggressive combination of therapeutic modalities, including the removal of subiris abscesses, might be needed for the successful resolution of Fusarium endophthalmitis.
描述用于成功根除镰刀菌性眼内炎的多种治疗方式的联合应用。
干预性病例系列。
3例连续性角膜相关镰刀菌性眼内炎患者。
在传统治疗方法失败后，对每位患者采用玻璃体内及长期大剂量全身伏立康唑、局部抗真菌药物以及手术干预的联合治疗，包括穿透性角膜移植术、晶状体切除术和内镜引导下经平坦部玻璃体切除术。
所有3例感染均完全消退，最终Snellen视力评分为20/50至20/70。
对于成功解决镰刀菌性眼内炎，可能需要积极联合多种治疗方式，包括清除虹膜下脓肿。
