Ford J C, Hackney D B
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA.
Magn Reson Med. 1997 Mar;37(3):387-94. doi: 10.1002/mrm.1910370315.
We have implemented a numerical method for calculation of the apparent diffusion coefficient (ADC) in spinal cord injury, which takes into account the distribution of axon diameters and permeability found in spinal cord white matter, as well as relative axonal volume. We propose a procedure for determining the status of axonal integrity from measured ADC values. These methods have been applied to a well characterized rat spinal cord injury model, affording a prediction of the increase in axonal permeability which is presumed to be closely related to functional deficit. ADC values are compared to those calculated from analytical formulas in the literature, and possible factors underlying the ADC behavior are explored. Calculated results indicate both axonal swelling and cell membrane permeability to be important factors contributing to ADC in traumatic spinal cord injury.
我们已经实现了一种用于计算脊髓损伤中表观扩散系数（ADC）的数值方法，该方法考虑了脊髓白质中轴突直径的分布、通透性以及相对轴突体积。我们提出了一种根据测量的ADC值确定轴突完整性状态的程序。这些方法已应用于一个特征明确的大鼠脊髓损伤模型，能够预测轴突通透性的增加，而轴突通透性的增加被认为与功能缺陷密切相关。将ADC值与文献中通过解析公式计算得到的值进行比较，并探讨了ADC行为背后的可能因素。计算结果表明，轴突肿胀和细胞膜通透性都是导致创伤性脊髓损伤中ADC变化的重要因素。
