Lee W J, Kim J C, Shyn K H
Department of Ophthalmology, Chung Ang University Medical Center, Seoul, Korea.
Korean J Ophthalmol. 1996 Dec;10(2):116-21. doi: 10.3341/kjo.1996.10.2.116.
We examined 18 cases of floppy eyelid syndrome, first reported in the Orient, in patients ranging in age from 11 to 55 years (mean 24 years); 16 were men and two were women. In contrast to previous reports in which almost all patients were obese men, only three of our patients were mildly obese. The most common abnormal corneal finding was punctate epithelial keratopathy (five patients-28%). Keratoconus was detectable in three patients (17%) overall; it was bilateral in one case and unilateral in two. Other miscellaneous corneal findings were corneal astigmatism and corneal opacity. In two cases, we found a familial tendency to skin hyperextensibility and joint hypermobility, and in one case, floppy eyelid syndrome developed after pars plana vitrectomy. The pathogenesis of the syndrome is still unknown, but our findings suggest that the more important pathogenetic risk factors are not obesity and sleeping pattern, but genetic collagen and/or elastin abnormality.
我们检查了18例东方首次报道的睑皮松弛综合征患者，年龄在11岁至55岁之间（平均24岁）；其中16例为男性，2例为女性。与之前几乎所有患者均为肥胖男性的报道不同，我们的患者中只有3例轻度肥胖。最常见的角膜异常表现为点状上皮性角膜炎（5例患者，占28%）。总体上3例患者（17%）可检测到圆锥角膜；其中1例为双侧，2例为单侧。其他角膜异常表现包括角膜散光和角膜混浊。2例患者存在皮肤过度伸展和关节活动过度的家族倾向，1例患者在玻璃体视网膜手术后出现睑皮松弛综合征。该综合征的发病机制尚不清楚，但我们的研究结果表明，更重要的致病危险因素不是肥胖和睡眠模式，而是遗传性胶原和/或弹性蛋白异常。
