Sih J C, Nash S A
Prostaglandins. 1977 Sep;14(3):407-12. doi: 10.1016/0090-6980(77)90256-8.
This report describes the preparation of various 2,3-dinor-PGFalpha prostaglandins. Of particular importance is the synthesis of 2,3-dinor-15(S)-15-methyl PGF2alpha, the primary metabolite in the enzymatic degradation of 15(S)-15-methyl-PGF2alpha (1). Introduction of the three carbon beta,gamma-unsaturated carboxyl side chain was achieved in a one-step Wittig reaction. The 2,3-dinor structural assignments were established by carbon magnetic resonance (cmr) spectroscopy.
本报告描述了各种2,3-二去甲-PGFα前列腺素的制备方法。特别重要的是2,3-二去甲-15(S)-15-甲基-PGF2α的合成，它是15(S)-15-甲基-PGF2α酶促降解的主要代谢产物(1)。通过一步维蒂希反应引入了三碳β,γ-不饱和羧基侧链。2,3-二去甲结构归属通过碳磁共振(cmr)光谱确定。
