Hof P R
Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA.
Eur Neurol. 1997;37(2):71-81. doi: 10.1159/000117414.
Since the classical descriptions of the symptomatology and neuropathologic characteristics of Alzheimer's disease (AD), we have witnessed a considerable increase in the knowledge of the morphologic and molecular features not only of AD, but also of normal brain aging. In spite of this progress, the pathogenetic events that differentiate normal brain aging from the early stages of dementia and may lead eventually to AD are not completely understood. This article reviews the possible relationships between the localization of cellular pathologic changes in AD and the distribution of neuronal components of the hippocampal and neocortical circuitry that are affected by these alterations. The relative vulnerability or resistance of a given neuronal type to the degenerative process is discussed in order to provide correlates of the distribution of cellular pathologic changes, neurochemical phenotype related to vulnerability, and affected hippocampal and neocortical circuits.
自从对阿尔茨海默病（AD）的症状学和神经病理学特征进行经典描述以来，我们见证了不仅关于AD，而且关于正常脑老化的形态学和分子特征的知识有了显著增加。尽管取得了这一进展，但区分正常脑老化与痴呆早期阶段并最终可能导致AD的致病事件仍未完全明了。本文综述了AD中细胞病理变化的定位与受这些改变影响的海马和新皮质神经回路的神经元成分分布之间的可能关系。讨论了特定神经元类型对退行性过程的相对易损性或抗性，以便提供细胞病理变化分布、与易损性相关的神经化学表型以及受影响的海马和新皮质回路之间的相关性。
