Korenaga D, Orita H, Maekawa S, Itasaka H, Ikeda T, Sugimachi K
Department of Surgery, Fukuoka City Hospital, Kyushu University, Japan.
Hepatogastroenterology. 1997 Jan-Feb;44(13):78-83.
This study was done to determine the potential role of sex steroid hormone receptors in the development of human colorectal cancer.
Receptors for estrogen (ER) and progesterone(PgR) were investigated in surgical specimens from 22 patients with colorectal cancer, using enzyme immunoassay. These values were examined in relation to cell kinetics parameters determined by DNA flow cytometry.
ER and PgR were detected in 27% and 41%, respectively. There were no significant differences in the expression of ER or PgR according to the age, sex of the patients, tumor size, location, histological differentiation and lymph node metastasis. Although ER status appeared to be independent of DNA parameters, there were better correlations of PgR-negative tumors with increased hyperaneuploid levels. There were significantly higher values of heterogeneity index score in PgR-negative tumors compared with PgR-positive tumors. In the multiple regression analysis, PgR levels proved to be a major independent factor for changes in DNA index and heterogeneity index score.
The PgR status is a critical factor for determining the proliferative activity of colorectal cancer tissue and may play a biological role in regulating the growth of the tumor.
本研究旨在确定性甾体激素受体在人类结直肠癌发生发展中的潜在作用。
采用酶免疫测定法，对22例结直肠癌患者手术标本中的雌激素受体（ER）和孕激素受体（PgR）进行检测。将这些值与通过DNA流式细胞术测定的细胞动力学参数相关联进行分析。
ER和PgR的检测阳性率分别为27%和41%。根据患者的年龄、性别、肿瘤大小、位置、组织学分化及淋巴结转移情况，ER或PgR的表达无显著差异。虽然ER状态似乎与DNA参数无关，但PgR阴性肿瘤与超二倍体水平增加的相关性更好。与PgR阳性肿瘤相比，PgR阴性肿瘤的异质性指数评分显著更高。在多元回归分析中，PgR水平被证明是DNA指数和异质性指数评分变化的主要独立因素。
PgR状态是决定结直肠癌组织增殖活性的关键因素，可能在调节肿瘤生长中发挥生物学作用。
