Milkiewicz P, Olliff S, Johnson A P, Elias E
Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.
Eur J Gastroenterol Hepatol. 1997 Feb;9(2):217-20. doi: 10.1097/00042737-199702000-00022.
Obstructive sleep apnoea syndrome (OSAS) appears to be an extremely rare complication of carcinoid syndrome and has not yet been reported in the literature. We describe a 75-year-old patient with a history of bronchial carcinoid who besides typical carcinoid syndrome symptoms developed sleep disturbance and day lethargy caused by massive facial and nasal tissue oedema. Sleep apnoea was confirmed by sleep study. Abdominal ultrasound and computed tomography (CT) scan showed the presence of multiple liver metastases. Because the patient did not respond to octreotide therapy, embolization of the hepatic artery was performed. After this procedure we observed dramatic improvement of the patient's life quality, and rapid disappearance of facial swelling and sleep apnoea symptoms. We conclude that hepatic artery embolization appeared to be an effective method of abolishing obstructive sleep apnoea associated with carcinoid syndrome.
阻塞性睡眠呼吸暂停综合征（OSAS）似乎是类癌综合征极为罕见的并发症，文献中尚未有报道。我们描述了一位75岁有支气管类癌病史的患者，除了典型的类癌综合征症状外，还因面部和鼻腔组织大量水肿出现睡眠障碍和日间嗜睡。睡眠研究证实存在睡眠呼吸暂停。腹部超声和计算机断层扫描（CT）显示有多处肝转移。由于患者对奥曲肽治疗无反应，遂进行了肝动脉栓塞术。该手术后，我们观察到患者生活质量显著改善，面部肿胀和睡眠呼吸暂停症状迅速消失。我们得出结论，肝动脉栓塞术似乎是消除与类癌综合征相关的阻塞性睡眠呼吸暂停的有效方法。
