Bjerring P, Zachariae H, Søgaard H
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
Acta Derm Venereol. 1997 Jan;77(1):59-61. doi: 10.2340/0001555577059061.
Eleven patients with chronic plaque psoriasis were treated with the flashlamp-pumped pulsed dye laser and 6 of the same patients were at the same time treated by dermabrasion. Complete remissions were observed in 3 patients following laser-treatment and in 5 of 6 after dermabrasion. The observation periods were from 4 to 9 months. Our data suggest that the mechanism of the reversed Köbner phenomenon, which is thought to be responsible for the results of dermabrasion, is partly due to destruction of the dermal papillary vasculature. Partial responses were seen in 6 laser-treated and in one patient treated by dermabrasion. Two patients showed no response to laser treatment. These clinically unsatisfactory results can be explained by the great variety in thickness of plaques and in variability of penetration of the laser light. Measurements of absorption and scattering properties of plaques scheduled for laser treatment could probably allow improvements in the technique by optimizing laser beam diameter and pulse duration as well as wavelength and energy levels. The use of the dye laser is far less traumatic to the patient than dermabrasion.
11例慢性斑块状银屑病患者接受了闪光灯泵浦脉冲染料激光治疗，其中6例同时接受了磨皮治疗。激光治疗后3例患者完全缓解，磨皮治疗的6例患者中有5例完全缓解。观察期为4至9个月。我们的数据表明，被认为是磨皮治疗结果原因的反向同形反应机制，部分是由于真皮乳头血管系统的破坏。6例接受激光治疗的患者和1例接受磨皮治疗的患者出现部分反应。2例患者对激光治疗无反应。这些临床效果不理想的结果可以用斑块厚度的巨大差异和激光穿透的变异性来解释。对计划进行激光治疗的斑块的吸收和散射特性进行测量，可能通过优化激光束直径、脉冲持续时间以及波长和能量水平来改进技术。与磨皮治疗相比，染料激光的使用对患者造成的创伤要小得多。
