Kaur G, Sharma P, Bhardwaj S, Kaur G
Department of Biotechnology, Guru Nanak Dev University, Amritsar, India.
Mol Cell Biochem. 1997 Feb;167(1-2):107-11. doi: 10.1023/a:1006876718783.
The effect of intraventricular (IVT) administration of GABAA receptor agonist muscimol and GABAB receptor agonist, baclofen was examined on the activity of acetylcholinesterase (AChE), monoamine oxidase (MAO) and Na+, K(+)-ATPase in discrete areas of brain from estrogen-progesterone primed ovariectomized rats. AChE enzyme activity was increased in two subcellular fractions (soluble and total particulate) studied, with statistically significant changes in cerebral hemispheres (CH), cerebellum (CB), thalamus (TH) and hypothalamus (HT), Na+, K(+)-ATPase enzyme activity was decreased in both these fractions. MAO activity increased significantly in CH, TH and HT. The presented results suggest a functional relationship between GABAergic (inhibitory), cholinergic and monoaminergic (excitatory) systems by affecting the rate of degradation of the excitatory neurotransmitters and Na+, K(+)-ATPase.
研究了向经雌激素 - 孕酮预处理的去卵巢大鼠脑的离散区域脑室内（IVT）注射γ-氨基丁酸A（GABAA）受体激动剂蝇蕈醇和γ-氨基丁酸B（GABAB）受体激动剂巴氯芬对乙酰胆碱酯酶（AChE）、单胺氧化酶（MAO）以及Na +，K（+）-ATP酶活性的影响。在所研究的两个亚细胞组分（可溶性和总颗粒性）中，AChE酶活性增加，在大脑半球（CH）、小脑（CB）、丘脑（TH）和下丘脑（HT）中有统计学上的显著变化，这两个组分中的Na +，K（+）-ATP酶活性均降低。MAO活性在CH、TH和HT中显著增加。呈现的结果表明，通过影响兴奋性神经递质和Na +，K（+）-ATP酶的降解速率，GABA能（抑制性）、胆碱能和单胺能（兴奋性）系统之间存在功能关系。
