Arber D A, Strickler J G, Weiss L M
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, U.S.A.
Am J Surg Pathol. 1997 Mar;21(3):334-8. doi: 10.1097/00000478-199703000-00010.
Lymphangiomas of the spleen may occur as part of lymphangiomatosis or may represent solitary lesions. Solitary splenic lymphangiomas are described traditionally as subcapsular, multicystic proliferations that are often incidental findings. Six cases of splenic tumors with morphologic features similar to those described for solitary lymphangioma were studied using an immunohistochemical panel that included epithelial and vascular markers. None of the patients had evidence of lymphangiomatosis, and all tumors were incidental findings in splenectomy specimens. All cases demonstrated lining cells that were positive for keratin and the mesothelial cell-associated antibody HBME-1 but were negative for the vascular markers Factor VIII-related antigens, CD31, and CD34. The immunohistochemical findings are suggestive of a mesothelial derivation of these multicystic proliferations rather than representing true lymphangiomas.
脾脏淋巴管瘤可能作为淋巴管瘤病的一部分出现，也可能表现为孤立性病变。传统上，孤立性脾淋巴管瘤被描述为包膜下的多囊性增生，常为偶然发现。我们使用包括上皮和血管标志物的免疫组织化学检测组合，对6例具有与孤立性淋巴管瘤相似形态学特征的脾脏肿瘤进行了研究。所有患者均无淋巴管瘤病的证据，所有肿瘤均为脾切除标本中的偶然发现。所有病例的衬里细胞对角蛋白和间皮细胞相关抗体HBME-1呈阳性，但对血管标志物VIII因子相关抗原、CD31和CD34呈阴性。免疫组织化学结果提示这些多囊性增生来源于间皮，而非真正的淋巴管瘤。
