Girard J P, Springer T A
Laboratoire de Biologie Moléculaire Eucaryote (LBME) du CNRS, Toulouse, France.
Immunol Today. 1995 Sep;16(9):449-57. doi: 10.1016/0167-5699(95)80023-9.
High endothelial venules (HEVs) are specialized postcapillary venules found in lymphoid tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean-Philippe Girard and Timothy Springer highlight the unique properties of HEV endothelium, discuss the molecular mechanisms controlling HEV specialization and review evidence suggesting that HEVs could play an important role in the pathogenesis of chronic inflammatory diseases.
高内皮微静脉（HEV）是在淋巴组织中发现的特化毛细血管后微静脉，其支持淋巴细胞从血液中大量渗出。在此，让 - 菲利普·吉拉德和蒂莫西·斯普林格强调了HEV内皮的独特特性，讨论了控制HEV特化的分子机制，并综述了表明HEV可能在慢性炎症性疾病发病机制中发挥重要作用的证据。
