Kerdesky F A, Brooks C D, Hulkower K I, Bouska J B, Bell R L
Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
Bioorg Med Chem. 1997 Feb;5(2):393-6. doi: 10.1016/s0968-0896(96)00255-6.
Representative examples of NSAID cyclooxygenase inhibitors such as naproxen, ibufenac, ibuprofen, and butibufen have been transformed into 5-lipoxygenase inhibitors by replacement of the carboxylic acid moiety with a 4-hydroxythiazole group.
非甾体抗炎药环氧化酶抑制剂的代表性实例，如萘普生、异丁苯丙酸、布洛芬和布替布芬，已通过用4-羟基噻唑基团取代羧酸部分而转化为5-脂氧合酶抑制剂。
