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Is scrapie solely a genetic disease?

作者信息

Hunter N, Cairns D, Foster J D, Smith G, Goldmann W, Donnelly K

出版信息

Nature. 1997 Mar 13;386(6621):137. doi: 10.1038/386137a0.

DOI:10.1038/386137a0
PMID:9062185
Abstract
摘要

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Is scrapie solely a genetic disease?羊瘙痒症仅仅是一种遗传性疾病吗？
Nature. 1997 Mar 13;386(6621):137. doi: 10.1038/386137a0.
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Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene.
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Amino acid polymorphisms of PrP with reference to onset of scrapie in Suffolk and Corriedale sheep in Japan.
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Swaledale sheep affected by natural scrapie differ significantly in PrP genotype frequencies from healthy sheep and those selected for reduced incidence of scrapie.受自然痒病影响的斯瓦尔代尔羊在朊蛋白基因型频率上与健康羊以及那些因痒病发病率降低而被选育的羊存在显著差异。
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An Amino Acid Substitution Found in Animals with Low Susceptibility to Prion Diseases Confers a Protective Dominant-Negative Effect in Prion-Infected Transgenic Mice.在对朊病毒疾病易感性低的动物中发现的一种氨基酸取代赋予了朊病毒感染的转基因小鼠保护性显性负效应。
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