Mennen L I, Witteman J C, den Breeijen J H, Schouten E G, de Jong P T, Hofman A, Grobbee D E
Department of Epidemiology and Biostatistics, Erasmus University Rotterdam, Netherlands.
Am J Clin Nutr. 1997 Mar;65(3):732-6. doi: 10.1093/ajcn/65.3.732.
Considerable evidence suggests that a high concentration of coagulation factor VII is a risk factor for ischemic heart disease. Factor VII is known to be influenced by dietary fat and probably by dietary fiber in young and middle-aged people. There are no data available in elderly people and the effects of different types of fat are unclear. This study examines the relation of factor VII activity (factor VIIc) with dietary fat and fiber in The Rotterdam Study. The Rotterdam Study is a population-based study among 7983 men and women aged > or = 55 y. Factor VIIc was measured in 3007 subjects (1730 women and 1277 men aged 67.3 +/- 7.8 and 66.3 +/- 7.0 y, respectively). Measurements included cardiovascular risk factors and habitual diet was assessed by a semiquantitative food-frequency questionnaire. Associations that were significant or nearly significant differed for some nutrients between men and women. Total fat intake showed a direct association with factor VIIc only in women (beta = 0.1%/g; 95% CI: 0.01, 0.20). Saturated fat intake was associated with factor VIIc in women (beta = 0.18%/g; 95% CI: 0.001, 0.36) and in men (beta = 0.11%/g; 95% CI: -0.06, 0.27). Monounsaturated fat was positively related to factor VIIc in women (beta = 0.17%/g; 95% CI: -0.05, 0.39) and polyunsaturated fat was inversely associated with factor VIIc in men (beta = -0.15%/g; 95% CI: -0.33, 0.03). Fiber intake was inversely associated with factor VIIc in both men (beta = -0.31%/g; 95% CI: -0.57, -0.06) and women (beta = -0.36%/g; 95% CI: -0.63, -0.09). No associations were found for energy intake. In elderly persons, factor VIIc is associated with fat and fiber intake. This suggests that factor VIIc is influenced by nutritional factors, even in old age.
大量证据表明，凝血因子VII浓度过高是缺血性心脏病的一个危险因素。已知在年轻人和中年人中，凝血因子VII受膳食脂肪影响，可能还受膳食纤维影响。但针对老年人的数据尚不可得，而且不同类型脂肪的影响也不清楚。本研究在鹿特丹研究中考察了凝血因子VII活性（因子VIIc）与膳食脂肪和膳食纤维之间的关系。鹿特丹研究是一项基于人群的研究，研究对象为7983名年龄≥55岁的男性和女性。对3007名受试者（1730名女性和1277名男性，年龄分别为67.3±7.8岁和66.3±7.0岁）进行了因子VIIc测定。测量内容包括心血管危险因素，并通过半定量食物频率问卷评估习惯性饮食。男性和女性在某些营养素方面，显著或接近显著的关联有所不同。总脂肪摄入量仅在女性中与因子VIIc呈直接关联（β=0.1%/克；95%CI：0.01，0.20）。饱和脂肪摄入量在女性中（β=0.18%/克；95%CI：0.001，0.36）和男性中（β=0.11%/克；95%CI：-0.06，0.27）均与因子VIIc相关。单不饱和脂肪在女性中与因子VIIc呈正相关（β=0.17%/克；95%CI：-0.05，0.39），多不饱和脂肪在男性中与因子VIIc呈负相关（β=-0.15%/克；95%CI：-0.33，0.
