Iliev D, Hinnen U, Elsner P
Department of Dermatology, University Hospital Zurich, Switzerland.
Contact Dermatitis. 1997 Feb;36(2):101-3. doi: 10.1111/j.1600-0536.1997.tb00422.x.
The identification of subjects with increased susceptibility to irritants may play an important rôle in the prevention of irritant contact dermatitis. A short and quick method of non-invasive testing for assessing irritant sensitivity was developed by Wilhelm and coworkers in 1990, based on the alkali resistance test of Burckhardt. In order to determine the reproducibility of this screening method, 204 healthy metalworker trainees were tested 2 x according to Wilhelm within an interval of 6 months. No statistically-significant correlation could be shown, indicating that the reproducibility of this screening method is low. Therefore, we propose applying not just a single test for the assessment of skin irritability, but a series of tests, in order to improve the reliability of this kind of testing.
识别对刺激物易感性增加的个体对于预防刺激性接触性皮炎可能具有重要作用。1990年，威廉及其同事基于伯克哈特的耐碱性试验，开发了一种用于评估刺激敏感性的简短快速的非侵入性测试方法。为了确定这种筛查方法的可重复性，204名健康的金属加工学员在6个月的间隔内按照威廉的方法进行了2次测试。未显示出统计学上的显著相关性，这表明这种筛查方法的可重复性较低。因此，我们建议不仅仅应用单一测试来评估皮肤易激性，而是应用一系列测试，以提高这类测试的可靠性。
