Bangha E, Hinnen U, Elsner P
Department of Dermatology, University of Zurich, Switzerland.
Acta Derm Venereol. 1996 Nov;76(6):450-2. doi: 10.2340/0001555576450452.
To reduce the incidence of irritant contact dermatitis, the development of screening methods to identify subjects with increased susceptibility to irritants is essential. In a pilot study on the comparison between two quick, non-invasive irritancy tests (dimethyl sulfoxide (DMSO) and sodium hydroxide (NaOH) with the time-consuming patch testing with sodium lauryl sulphate (SLS), no correlation between the "quick tests" and SLS patch testing was observed. In the present paper the results of irritancy testing in 181 metal worker trainees are presented. Experimental irritant contact dermatitis reactions were induced on the medial third of the volar forearm using SLS 0.5%, applied for 23 h and as "quick tests" DMSO 90% and 95% and a solution of 0.2% mol/l NaOH applied for 5 min. Assessment of skin irritability was made by visual scoring and measurement of transepidermal water loss. Except for a statistically significant relationship between the irritations by DMSO 90% and 95%, correlations between the different techniques were weak or non-existent. This is most probably due to different pathophysiological pathways for the irritant reactions. We therefore propose to use a spectrum of different tests in occupational dermatology for predicting the individual's risk of irritant contact dermatitis.
为降低刺激性接触性皮炎的发病率，开发用于识别对刺激物易感性增加的受试者的筛查方法至关重要。在一项关于两种快速、非侵入性刺激试验（二甲基亚砜（DMSO）和氢氧化钠（NaOH））与耗时的月桂基硫酸钠（SLS）斑贴试验比较的初步研究中，未观察到“快速试验”与SLS斑贴试验之间存在相关性。本文介绍了181名金属加工培训学员的刺激试验结果。使用0.5%的SLS在前臂掌侧内侧三分之一处诱导实验性刺激性接触性皮炎反应，敷用23小时，作为“快速试验”，使用90%和95%的DMSO以及0.2%mol/L的NaOH溶液敷用5分钟。通过视觉评分和经表皮水分流失测量来评估皮肤刺激性。除了90%和95%的DMSO引起的刺激之间存在统计学显著关系外，不同技术之间的相关性较弱或不存在。这很可能是由于刺激反应的不同病理生理途径所致。因此，我们建议在职业皮肤病学中使用一系列不同的试验来预测个体发生刺激性接触性皮炎的风险。
