Papotti M, Sambataro D, Marchesa P, Negro F
Dipartimento di Scienze Biomediche ed Oncologia Umana, Università di Torino, Italy.
Liver. 1997 Feb;17(1):47-52. doi: 10.1111/j.1600-0676.1997.tb00778.x.
A case of primary liver cancer showing combined hepatocellular and cholangiocellular features and an associated pseudosarcomatous (schwannomatous) component is presented. Histologically, compact microtrabecular and glandular patterns in a dense fibrous stroma were recognized. The latter showed transition towards spindle cell sarcomatous growth in several areas of both the primary and the lymph-node metastasis. Glandular areas expressed acidic mucins and AE1-reactive keratins; albumin mRNA was detected by in situ hybridization in both trabecular and glandular areas. Vimentin and S-100 protein were mostly expressed in the pseudosarcomatous areas. Both the morphological patterns and the phenotypic features indicate that divergent differentiation along both epithelial and mesenchymal lineages took place in this rare primary liver tumor.
本文报告一例具有肝细胞和胆管细胞联合特征以及相关假肉瘤样（神经鞘瘤样）成分的原发性肝癌。组织学上，在致密纤维间质中可见紧密的微小梁和腺管样结构。在原发灶和淋巴结转移灶的几个区域，后者显示向梭形细胞肉瘤样生长转变。腺管样区域表达酸性黏蛋白和AE1反应性角蛋白；原位杂交在小梁和腺管样区域均检测到白蛋白mRNA。波形蛋白和S-100蛋白主要在假肉瘤样区域表达。形态学模式和表型特征均表明，在这种罕见的原发性肝肿瘤中发生了上皮和间充质谱系的分化。
