Testosterone propionate prevents cisplatin induced inhibition of renal beta-glucuronidase activity in rats.

The activities of lysosomal enzymes in the kidney of rats (100 and 30 days old) were studied following treatment with cisplatin and cisplatin with testosterone propionate for 2 alternate days. The decreased activity of renal beta-glucuronidase during cisplatin treatment reflected the decreased availability of testosterone, while activity was increased in the rats supplemented with testosterone. The decreased alkaline phosphatase activity in all the experimental groups may be due to the inhibition of cellular processes exerted by cisplatin acting directly on the brush border membrane of kidney.