Arroyo J G, Schatz H, McDonald R, Johnson R N
Department of Ophthalmology, University of California at San Francisco, USA.
Am J Ophthalmol. 1997 Mar;123(3):377-85. doi: 10.1016/s0002-9394(14)70134-5.
To determine the features of combined fluorescein and indocyanine green videoangiography after acute retinal pigment epithelial tears associated with age-related macular degeneration.
We performed combined fluorescein and indocyanine green videoangiography in three eyes of three patients 2 days to 2 months after the development of tears of the retinal pigment epithelium.
The area of exposed choroid in a retinal pigment epithelial tear shows intense hyperfluorescence in fluorescein videoangiography; in contrast, this area demonstrates near-normal choroidal fluorescence on an indocyanine green videoangiogram. The folded and retracted flap of retinal pigment epithelium in a retinal pigment epithelial tear discloses marked hypofluorescence on the fluorescein videoangiogram; in contrast, this flap of retinal pigment epithelium displays varying degrees of hyperfluorescence on the indocyanine green videoangiogram.
The angiographic differences between fluorescein and indocyanine green result from the distinct biophysical properties of these two dyes as well as from the differential penetration of their fluorescence through such pigmented structures as retinal pigment epithelium. Compared with fluorescein videoangiography, indocyanine green videoangiography allows better visualization of choroidal neovascular membranes within the rolled-up and retracted flap of the retinal pigment epithelial tear.
确定与年龄相关性黄斑变性相关的急性视网膜色素上皮撕裂后联合荧光素和吲哚菁绿视频血管造影的特征。
在视网膜色素上皮撕裂发生后2天至2个月，对3例患者的3只眼进行了荧光素和吲哚菁绿联合视频血管造影。
视网膜色素上皮撕裂中暴露脉络膜的区域在荧光素视频血管造影中显示强烈的高荧光；相比之下，该区域在吲哚菁绿视频血管造影上显示接近正常的脉络膜荧光。视网膜色素上皮撕裂中折叠和回缩的瓣片在荧光素视频血管造影上显示明显的低荧光；相比之下，该视网膜色素上皮瓣片在吲哚菁绿视频血管造影上显示不同程度的高荧光。
荧光素和吲哚菁绿之间的血管造影差异源于这两种染料不同的生物物理特性，以及它们的荧光通过视网膜色素上皮等色素结构的不同穿透情况。与荧光素视频血管造影相比，吲哚菁绿视频血管造影能更好地显示视网膜色素上皮撕裂的卷起和回缩瓣片内的脉络膜新生血管膜。
