翼状胬肉患者结膜中p53肿瘤抑制基因的异常表达。
Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium.
作者信息
Tan D T, Lim A S, Goh H S, Smith D R
机构信息
Singapore National Eye Centre, Republic of Singapore.
出版信息
Am J Ophthalmol. 1997 Mar;123(3):404-5. doi: 10.1016/s0002-9394(14)70141-2.
PURPOSE
To determine whether pterygium is a disorder of abnormal growth by examining the expression of the p53 gene in the conjunctiva of patients with pterygium.
METHODS
Immunostaining for abnormal expression of p53 was performed using mouse monoclonal antibody to human p53, pAb 240, on six eyes with primary pterygium and two eyes with recurrent pterygium.
RESULTS
In three of the eight eyes with pterygium, specimens were positive for abnormal expression in the epithelium of the pterygium and in the superior bulbar conjunctiva.
CONCLUSION
Abnormal p53 expression in the epithelium of primary and recurrent pterygium specimens suggests that pterygium is a growth disorder rather than a degeneration.
目的
通过检测翼状胬肉患者结膜中p53基因的表达，确定翼状胬肉是否为异常生长疾病。
方法
使用抗人p53小鼠单克隆抗体pAb 240对6只原发性翼状胬肉眼和2只复发性翼状胬肉眼进行p53异常表达的免疫染色。
结果
在8只翼状胬肉眼中，有3只的标本在翼状胬肉上皮和上睑球结膜中异常表达呈阳性。
结论
原发性和复发性翼状胬肉标本上皮中p53的异常表达表明翼状胬肉是一种生长紊乱而非退行性病变。
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