Sakoonwatanyoo Pornpilas, Tan Donald T H, Smith Duncan R
Molecular Pathology Laboratory, Institute of Molecular Biology and Genetics, Mahidol University, Salaya Campus, Nakorn Pathom, Thailand.
Cornea. 2004 Jan;23(1):67-70. doi: 10.1097/00003226-200401000-00011.
The p63 gene has been identified as a marker of epithelial stem cells. Because pterygium may arise through an expansion of the proliferative capacity of the conjunctiva, we sought to document the expression of p63 in normal conjunctiva and pterygium specimens.
Immunostaining for p63 expression was performed on 10 pairs of pterygium and normal conjunctiva using a monoclonal antibody directed against human p63.
Immunopositive reactions were seen in all samples. Levels of p63-positive cells were not statistically different between pterygium and normal conjunctivae (P = 0.7).
These results strongly support previous studies that indicate that pterygium arises as a result of incorrect control of cellular apoptosis rather than from an increase in proliferative capacity.
p63基因已被确定为上皮干细胞的标志物。由于翼状胬肉可能通过结膜增殖能力的扩大而产生，我们试图记录p63在正常结膜和翼状胬肉标本中的表达情况。
使用针对人p63的单克隆抗体，对10对翼状胬肉和正常结膜进行p63表达的免疫染色。
在所有样本中均观察到免疫阳性反应。翼状胬肉和正常结膜之间p63阳性细胞水平无统计学差异（P = 0.7）。
这些结果有力地支持了先前的研究，即翼状胬肉是细胞凋亡控制不当的结果，而非增殖能力增加所致。
