Hsieh S M, Hung C C, Chen M Y, Chuang C Y
Department of Internal Medicine, National Taiwan University Hospital, Taipei.
J Formos Med Assoc. 1996 Feb;95(2):166-9.
Syphilis has once again become a public health issue with the advent of human immunodeficiency virus (HIV) infection. We report a 28-year-old Chinese man with recently acquired HIV infection together with early neurosyphilis. His presentation of acute mononucleosis-like syndrome, lymphadenopathy, aseptic meningitis, positive central nervous syndrome and reactive Venereal Disease Research Laboratory test in his cerebrospinal fluid helped to reach the diagnosis. Paired serum Western blot tests for HIV infection performed 1 month apart revealed either a new appearance or an increasing intensity of bands for p17, p24, p31, gp41, p52, p55, p68, gp120 and gp160 suggesting recently acquired HIV infection. The lymphadenopathy disappeared spontaneously and the neurosyphilis responded well to 14 days of penicillin G therapy. The Western blot pattern, clinical course, laboratory data, and therapeutic response indicated that the acute retroviral syndrome and early central nervous system involvement caused by Treponema pallidum occurred concomitantly.
随着人类免疫缺陷病毒（HIV）感染的出现，梅毒再次成为一个公共卫生问题。我们报告一名28岁的中国男性，近期感染了HIV并患有早期神经梅毒。他表现为急性单核细胞增多症样综合征、淋巴结病、无菌性脑膜炎、中枢神经综合征阳性以及脑脊液性病研究实验室试验呈阳性，这些表现有助于做出诊断。间隔1个月进行的配对血清HIV感染蛋白免疫印迹试验显示，p17、p24、p31、gp41、p52、p55、p68、gp120和gp160条带出现新的条带或强度增加，提示近期感染了HIV。淋巴结病自行消失，神经梅毒对青霉素G治疗14天反应良好。蛋白免疫印迹模式、临床病程、实验室数据和治疗反应表明，梅毒螺旋体引起的急性逆转录病毒综合征和早期中枢神经系统受累同时发生。
