• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[通过联合给予N-甲基-N-亚硝基-N'-硝基胍前体诱导大鼠胃腺癌]

[Stomach adenocarcinoma induction in rats by the combined administration of N-methyl-N-nitroso-N'-nitroguanidine precursors].

作者信息

Kartasheva L A

出版信息

Vopr Onkol. 1977;23(8):54-7.

PMID:906407
Abstract

N-methyl-N'-nitroguanidine and sodium nitrite were administered as drinking water to non-inbred male rats at the level of Img/ml for over two years. Gastric adenocarcinomas were produced in 43.7% of rats surviving for 15.5 months when the first tumor was noticed. Gastric mucous membrane of other rats had morphological changes analogous to those induced by N-methyl-N-nitoroso-N'-nitroguanidine (MNNG). The results obtained indicate endogenous synthesis of MNNG from precursors in the stomach of rats.

摘要

将N-甲基-N'-硝基胍和亚硝酸钠以1毫克/毫升的浓度作为饮用水给予非近交系雄性大鼠，持续两年多。当首次发现肿瘤时，存活15.5个月的大鼠中有43.7%发生了胃腺癌。其他大鼠的胃黏膜出现了与N-甲基-N-亚硝基-N'-硝基胍（MNNG）诱导的类似形态学变化。所得结果表明大鼠胃中前体物质可内源性合成MNNG。

相似文献

1
[Stomach adenocarcinoma induction in rats by the combined administration of N-methyl-N-nitroso-N'-nitroguanidine precursors].[通过联合给予N-甲基-N-亚硝基-N'-硝基胍前体诱导大鼠胃腺癌]
Vopr Onkol. 1977;23(8):54-7.
2
[Induction of stomach tumors in rats by N-methyl-N-nitroso-N1-nitroguanidine].
Vopr Onkol. 1975;21(12):50-5.
3
[Effects of the method and regimen of administration on the carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine in rats].[给药方法和方案对大鼠N-甲基-N'-硝基-N-亚硝基胍致癌作用的影响]
Biull Eksp Biol Med. 1990 Feb;109(2):175-6.
4
Effect of flurbiprofen and 16,16-dimethyl prostaglandin E2 on gastrointestinal tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats: glandular epithelium of stomach and duodenum.氟比洛芬和16,16-二甲基前列腺素E2对N-甲基-N'-硝基-N-亚硝基胍诱导的大鼠胃肠道肿瘤发生的影响：胃和十二指肠的腺上皮
Cancer Res. 1990 Jan 15;50(2):381-4.
5
Effect of prolonged administration of gastrin on experimental carcinogenesis in rat stomach induced by N-methyl-N' -nitro-N-nitrosoguanidine.
Cancer Res. 1977 Jun;37(6):1808-10.
6
[Ultrastructure of experimental adenocarcinoma of the rat stomach following long term administration of MNNG].[长期给予MNNG后大鼠胃实验性腺癌的超微结构]
Gegenbaurs Morphol Jahrb. 1981;127(5):659-65.
7
[Effects of sex hormones on carcinogenesis of the stomach].
Gan To Kagaku Ryoho. 1983 Feb;10(2 Pt 2):433-42.
8
Genetic control of sensitivity of rats to gastrocarcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine.大鼠对N-甲基-N'-硝基-N-亚硝基胍诱导胃癌发生敏感性的遗传控制
IARC Sci Publ. 1982(41):603-9.
9
Molecular, biochemical and morphological aspects of the dynamics of rat stomach mucous membrane changes in experimental carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的实验性致癌过程中大鼠胃黏膜变化动力学的分子、生化和形态学方面
Arch Geschwulstforsch. 1989;59(5):313-22.
10
[Induction of gastric adenocarcinoma in mice by N-methyl-N'-nitro-N-nitroso guanidine and ultrastructural changes in the epithelial cells of prepyloric pit].[N-甲基-N'-硝基-N-亚硝基胍诱导小鼠胃腺癌及幽门前区上皮细胞超微结构变化]
Zhonghua Zhong Liu Za Zhi. 1982 Aug;4(3):161-4.