[Induction of stomach tumors in rats by N-methyl-N-nitroso-N1-nitroguanidine].

N-methyl-N-nitroso-N'-nitroguanidine was administered as drinking water to Wistar strain and non-inbred male rats in the dosage of 100 mKg/ml for 7 months, Adenocarcinomas of the stomach were produced in about 70% of rats. The first tumors in the glandular stomach were noticed in 10-12.5 months. Studies of the kinetics of morphological changes indicated that MNNG induced a damage to the mucous membrane, subsequent regenerative hyperplasia, adenomatous hyperplasia with cellular and structural atypism, atrophy, pylorization of the mucosa and development of gastric adenocarcinomas.