Crooks S R, McCaughey W J, Elliott C T, McEvoy J D, Hewitt S A
Department of Agriculture for Northern Ireland, Veterinary Sciences Division, Stormont, Belfast, UK.
Food Addit Contam. 1996 Feb-Mar;13(2):211-9. doi: 10.1080/02652039609374399.
The production of stable homogeneous reference materials containing the antimicrobial agent sulphadimidine in pig tissue is described. These were commissioned by the Community Bureau of Reference (BCR), established by the Commission of the European Communities, to promote improvements in analytical accuracy and to ensure uniformity of results determined by member states. Sulphadimidine-containing tissue powders (400 vials each of muscle, liver and kidney) were prepared by orally dosing pigs with drug, producing lyophilized tissue powders and blending these with negative tissues from unmedicated animals to achieve target concentrations. Details of the production process, the stabilizing procedure developed and the analytical assessments of homogeneity and stability are given.
