Campo M A, Rice E J, Kasik J W
Metrohealth Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA.
Am J Obstet Gynecol. 1996 May;174(5):1605-7. doi: 10.1016/s0002-9378(96)70614-2.
Our purpose was to identify genes that exhibit increased expression in the uterus during pregnancy.
A differential screen was performed against a pregnant mouse uterus complementary deoxyribonucleic acid library by use of probes derived from pregnant and nonpregnant uterus. Multiple clones related to the cytotoxic T-lymphocyte antigen-2 alpha gene were isolated.
Northern hybridization disclosed that message is present in both the gravid and nongravid uterus, but there is a substantial increase in expression during pregnancy. Expression is not found in a variety of other fetal and adult tissues evaluated (excluding placenta).
The uterus (or cells present within the uterus) constitutes a major site of in vivo expression for the cytotoxic T-lymphocyte antigen-2 alpha gene, and expression of this gene is increased during pregnancy.
