一些恶性肿瘤患者血清和白细胞中的超氧化物歧化酶活性

Superoxide dismutase activities in serum and white blood cells of patients with some malignancies.

作者信息

Abdel-Aziz A F, El-Naggar M M

机构信息

Chemistry Department, Faculty of Science, Mansoura University, Egypt.

出版信息

Cancer Lett. 1997 Feb 26;113(1-2):61-4. doi: 10.1016/s0304-3835(96)04590-9.

DOI:10.1016/s0304-3835(96)04590-9

PMID:9065802

Abstract

Superoxide dismutase (SOD) activity has been estimated in serum and leukocytes isolated from adults and children with acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma (NHL), Hodgkin's disease (HD) and neuroblastoma. Superoxide dismutase levels in leukocytes isolated from adult patients with HD, ALL and NHL were significantly higher than the corresponding control values. Serum SOD activity of adult patients with ALL and NHL was significantly decreased compared to the normal value, while its activity was not significantly changed in patients with HD. Marked deficiencies of leukocyte SOD levels in children with ALL, NHL, HD and neuroblastoma were found. There were no apparent differences in serum SOD activity in children suffering from ALL, NHL, HD and neuroblastoma. It is concluded that the assay of leukocyte SOD can be used to differentiate between HD and NHL in both adults and children.

摘要

已对急性淋巴细胞白血病（ALL）、非霍奇金淋巴瘤（NHL）、霍奇金病（HD）和神经母细胞瘤的成人及儿童患者血清及分离出的白细胞中的超氧化物歧化酶（SOD）活性进行了评估。HD、ALL和NHL成年患者分离出的白细胞中的超氧化物歧化酶水平显著高于相应的对照值。ALL和NHL成年患者的血清SOD活性与正常值相比显著降低，而HD患者的血清SOD活性无显著变化。发现ALL、NHL、HD和神经母细胞瘤患儿的白细胞SOD水平明显不足。ALL、NHL、HD和神经母细胞瘤患儿的血清SOD活性无明显差异。得出结论：白细胞SOD检测可用于区分成人和儿童的HD和NHL。