Roser W, Beckmann N, Wiesmann U, Seelig J
MR Center, University of Basel, Switzerland.
Magn Reson Imaging. 1996;14(10):1217-20. doi: 10.1016/s0730-725x(96)00243-3.
Using natural-abundance 13C magnetic resonance spectroscopy (MRS) on a conventional whole-body system operating at 1.5 T, the absolute hepatic glycogen concentration was noninvasively determined in a patient with type Ia glycogen storage disease. Furthermore, to assess the reliability of glycogen determination, hepatic glycogen content was assessed after an overnight fasting period in 35 healthy volunteers divided into two groups, one with a carbohydrate-rich diet, the other without any particular dietary preparation. In the patient, the glycogen concentration was found to be 458 mM. In the healthy subjects, average glycogen concentrations were 229 +/- 34 mM (mean +/- standard deviation) and 257 +/- 31 mM for the group without and with dietary preparation, respectively. The 13C-MRS results are in agreement with those obtained by conventional liver biopsy. 13C MRS in natural abundance may thus serve as a straightforward, fast, and noninvasive tool for quantification of the liver glycogen content in patients.
在一台运行于1.5T的传统全身系统上使用自然丰度13C磁共振波谱（MRS），对一名Ia型糖原贮积病患者的肝脏糖原绝对浓度进行了无创测定。此外，为评估糖原测定的可靠性，在35名健康志愿者禁食过夜后评估肝脏糖原含量，这些志愿者分为两组，一组采用富含碳水化合物的饮食，另一组未做任何特殊饮食准备。在该患者中，发现糖原浓度为458 mM。在健康受试者中，未做饮食准备组和做了饮食准备组的平均糖原浓度分别为229±34 mM（平均值±标准差）和257±31 mM。13C-MRS结果与通过传统肝活检获得的结果一致。因此，自然丰度的13C MRS可作为一种直接、快速且无创的工具，用于定量患者肝脏糖原含量。
