Wagner P, Röschke J, Frank C
Department of Psychiatry, University of Mainz, Germany.
Pharmacopsychiatry. 1997 Jan;30(1):16-22. doi: 10.1055/s-2007-979477.
Enhancement of beta power in the spontaneous EEG under the influence of benzodiazepine medication is a well known phenomenon under waking conditions as well as during sleep. On the other hand, in certain frequency bands EEG activity following external stimulation is also enhanced. Therefore, the question arises what relationship exists between pre- and poststimulus EEG under the influence of benzodiazepines. Is an augmentation of beta activity during benzodiazepine medication further enhanced when external stimulation is applied? In order to address this question we compared the spectral power of pre- and poststimulus EEG under 2.5 mg lorazepam during sleep with placebo conditions. The hypothesis tested was that of Basar (1980): if the beta power is high prior to the stimulation, no further enhancement following stimulation is observed. Our results confirm the hypothesis during sleep stages II and III. At the present time it is unclear whether this effect might be dose-dependent. In any case, the investigation presented here has furnished additional information on the mechanisms by which benzodiazepines alter the brain's electrical activity.
在苯二氮䓬类药物影响下，清醒状态以及睡眠期间，自发脑电图中β波功率增强是一种众所周知的现象。另一方面，在某些频段，外部刺激后的脑电图活动也会增强。因此，出现了一个问题，即在苯二氮䓬类药物影响下，刺激前和刺激后的脑电图之间存在什么关系。在使用苯二氮䓬类药物期间，当施加外部刺激时，β波活动的增强是否会进一步增强？为了解决这个问题，我们将睡眠期间服用2.5毫克劳拉西泮时刺激前和刺激后的脑电图频谱功率与安慰剂条件下进行了比较。所检验的假设是巴萨尔（1980年）提出的：如果刺激前β波功率较高，则刺激后不会观察到进一步增强。我们的结果在睡眠第二和第三阶段证实了这一假设。目前尚不清楚这种效应是否可能与剂量有关。无论如何，这里介绍的研究提供了关于苯二氮䓬类药物改变大脑电活动机制的更多信息。
