Roberts J A, Estuningsih E, Widjayanti S, Wiedosari E, Partoutomo S, Spithill T W
Balai Penelitian Veteriner, Bogor, West Java, Indonesia.
Vet Parasitol. 1997 Jan;68(1-2):69-78. doi: 10.1016/s0304-4017(96)01027-8.
High resistance of Indonesian thin tail (ITT) sheep against Fasciola gigantica has been confirmed. Naive ITT sheep had only 17% of the number of mature parasites collected from control St. Croix sheep. In contrast, the level of resistance of ITT sheep against F. hepatica was the same as that of the low resistance Merino breed after both primary and secondary infections. It is suggested that resistance of ITT sheep against F. gigantica was manifested in two phases. The major phase appeared to be specific to the ITT sheep : F. gigantica relationship, acting against immature parasites in both naive and previously exposed hosts and could be innate or acquired. The second phase appeared to be specific to F. gigantica, and was acquired, because it killed young adult parasites only after secondary infection. F. gigantica from ITT sheep were heavier than those from the St. Croix sheep, possible because feeding was impaired by more extensive liver damage in the latter. Approximately 45 F. gigantica killed 25-kg sheep before and during migration from the liver parenchyma into the bile ducts. Death was caused by haemorrhages into the liver parenchyma, bile ducts and peritoneum.
印度尼西亚细尾（ITT）绵羊对巨片吸虫具有高度抗性已得到证实。未感染过的ITT绵羊体内收集到的成熟寄生虫数量仅为对照圣克罗伊绵羊的17%。相比之下，ITT绵羊对肝片吸虫的抗性水平在初次和二次感染后与低抗性美利奴品种相同。有人认为，ITT绵羊对巨片吸虫的抗性表现在两个阶段。主要阶段似乎是ITT绵羊与巨片吸虫特有的关系，作用于未感染过和先前已接触过的宿主体内的未成熟寄生虫，可能是先天的或后天获得的。第二阶段似乎是巨片吸虫特有的，且是后天获得的，因为它仅在二次感染后杀死年轻的成虫。ITT绵羊体内的巨片吸虫比圣克罗伊绵羊体内的更重，可能是因为后者肝脏损伤更严重，影响了摄食。在从肝实质迁移到胆管之前及期间，约45条巨片吸虫可致25千克重的绵羊死亡。死亡原因是肝实质、胆管和腹膜出血。
