Roberts J A, Widjayanti S, Estuningsih E, Hetzel D J
Balai Penelitian Veterinar, Bogor, West Java, Indonesia.
Vet Parasitol. 1997 Mar;68(4):309-14. doi: 10.1016/s0304-4017(96)01068-0.
The genetic basis of the high resistance of Indonesian Thin Tail (ITT) sheep against Fasciola gigantica has been studied by measuring the resistance levels of ITT sheep, St. Croix sheep and their F2 and F3 crossbreds. All of the sheep were bred and reared in the same environment. Approximately half of the F2 and F3 crossbreds were as resistant as the ITT parental breed, one-quarter had the low resistance of the St. Croix parental breed and the rest had an intermediate level of resistance. It is concluded that the high resistance is determined by a major gene with incomplete dominance. The prevalence of the gene in the ITT sheep population is estimated to be about 90%. The resistance may be innate or acquired; but, regardless of the mechanism, it could be used to control fasciolosis caused by F. gigantica by breed substitution or by crossbreeding with other breeds of sheep.
通过测量印度尼西亚细尾（ITT）绵羊、圣克罗伊绵羊及其F2和F3杂交后代的抗性水平，对ITT绵羊对巨片吸虫的高抗性遗传基础进行了研究。所有绵羊均在相同环境中繁殖和饲养。大约一半的F2和F3杂交后代与ITT亲本品种一样具有抗性，四分之一具有圣克罗伊亲本品种的低抗性，其余的具有中等抗性水平。得出的结论是，高抗性由一个不完全显性的主基因决定。该基因在ITT绵羊群体中的流行率估计约为90%。这种抗性可能是先天的或后天获得的；但是，无论其机制如何，它都可用于通过品种替代或与其他绵羊品种杂交来控制由巨片吸虫引起的片形吸虫病。
