Thomas H, Gönnert R
Z Parasitenkd. 1977 Jul 21;52(2):117-27. doi: 10.1007/BF00389898.
Praziquantel (EMBAY 8440, Droncit) is a new type of acylated isoquinoline-pyrazine. A single oral or subcutaneous dose of the compound is reliably effective against juvenile and adult cestodes in mice and rats. For the first time, with praziquantel a compound is available that is also effective on cestodes in the bile-duct. Using Hymenolepis nana in mice we were able to show that age, sex, strain and intensity of infestation of the host have no influence on the efficacy. The onset of the effect of praziquantel in vivo is rapid. Within 10 min the parasites were immobilized and contracted and excreted within a few hours with the faeces.
吡喹酮（EMBAY 8440，Droncit）是一种新型的酰化异喹啉吡嗪。该化合物单次口服或皮下给药对小鼠和大鼠体内的幼年和成年绦虫均有可靠疗效。首次有了吡喹酮这种对胆管内绦虫也有效的化合物。利用小鼠体内的微小膜壳绦虫，我们能够证明宿主的年龄、性别、品系和感染强度对疗效均无影响。吡喹酮在体内起效迅速。10分钟内寄生虫就会被固定并收缩，数小时内随粪便排出。
