Hinze S, Bergmann K C, Løwenstein H, Hansen G N
Allergie- und Asthmaklinik Wilhelm Gronemeyer, Kuranstalten und Forschungsinstitute Bad Lippspringe GmbH, Bad Lippspringe, Germany.
Int Arch Allergy Immunol. 1997 Mar;112(3):231-7. doi: 10.1159/000237459.
Farmers (N = 45) suffering from occupational cow hair asthma were visited at home to evaluate the concentration of cow hair major allergen Bos d 2 in the house dust and to correlate these results with measures of avoidance, degree of sensitization, clinical symptoms, and lung function. Bos d 2 was determined by rocket immunoelectrophoresis. In dust of tiles and linoleum Bos d 2 was difficult to detect, whereas dust samples of carpets often contained high concentrations of the allergen (50-520 micrograms/g fine dust). Bos d 2 levels were significantly higher when barn and living quarters were in the same building. Concentrations of cow hair-specific IgE were correlated with concentrations of Bos d 2 in house dust samples. A concentration of 20-29 micrograms Bos d 2 per gram of house dust could be established as threshold value for relevant IgE sensitization. Avoiding the barn is not a sufficient avoidance measure for cow hair asthmatics if the partner continues cattle farming. Cessation of cattle farming and avoiding the former barn results in a marked reduction in Bos d 2 concentration in living quarters, a decreased degree of sensitization, and a reduced symptom score. Farmers with cow hair asthma should avoid cattle and thoroughly clean all carpets in the living quarters to avoid continuous cow allergen exposure.
研究人员对45名患有职业性牛毛哮喘的农民进行了家访，以评估室内灰尘中牛毛主要过敏原Bos d 2的浓度，并将这些结果与避免接触措施、致敏程度、临床症状和肺功能进行关联。Bos d 2通过火箭免疫电泳法测定。在瓷砖和油毡地面的灰尘中很难检测到Bos d 2，而地毯的灰尘样本中往往含有高浓度的该过敏原（50 - 520微克/克细尘）。当谷仓和居住区域在同一建筑物内时，Bos d 2水平显著更高。牛毛特异性IgE的浓度与室内灰尘样本中Bos d 2的浓度相关。每克室内灰尘中Bos d 2浓度为20 - 29微克可被确定为相关IgE致敏的阈值。如果伴侣继续从事养牛业，对于牛毛哮喘患者来说，仅避免进入谷仓并非充分的避免接触措施。停止养牛并避免进入以前的谷仓会导致居住区域Bos d 2浓度显著降低、致敏程度减轻以及症状评分降低。患有牛毛哮喘的农民应避免接触牛，并彻底清洁居住区域的所有地毯，以避免持续接触牛过敏原。
