Kuiper-Kramer P A, Huisman C M, Van der Molen-Sinke J, Abbes A, Van Eijk H G
Sophia Hospital, Zwolle, The Netherlands.
Acta Haematol. 1997;97(3):127-31. doi: 10.1159/000203669.
The presence of transferrin receptors on erythroblasts in patients with iron deficiency, anaemia of chronic disease (ACD) and myelodysplastic syndrome (MDS) was studied by two-colour analysis on a flow cytometer. CD 71 was used to quantify the number of transferrin receptors and GLY-A to identify erythroblasts. In cases of iron deficiency, the number of transferrin receptors was increased on part of the erythroblasts thus facilitating iron uptake by the cells. In patients with ACD or MDS, a decrease of the number of transferrin receptors on erythroblasts was found. This leads to the conclusion that the ineffective response to iron therapy in cases of ACD and MSD can be explained by a decline of transferrin receptors on the red cells.
通过流式细胞仪双色分析，研究了缺铁性贫血、慢性病贫血（ACD）和骨髓增生异常综合征（MDS）患者成红细胞上转铁蛋白受体的存在情况。采用CD 71定量转铁蛋白受体数量，GLY-A识别成红细胞。在缺铁性贫血病例中，部分成红细胞上的转铁蛋白受体数量增加，从而促进细胞对铁的摄取。在ACD或MDS患者中，发现成红细胞上的转铁蛋白受体数量减少。由此得出结论，ACD和MSD病例中铁治疗无效可通过红细胞上转铁蛋白受体数量下降来解释。
