Thines E, Arendholz W R, Anke H, Sterner O
University of Kaiserslautern, Department of Biotechnology, Germany.
J Antibiot (Tokyo). 1997 Jan;50(1):13-7. doi: 10.7164/antibiotics.50.13.
A novel metabolite, benesudon, possessing antibacterial, antifungal, cytotoxic and phytotoxic activities, was isolated from submerged cultures of the ascomycete Mollisia benesuada. Benesudon contains a reactive alpha-methyleneketone moiety which is believed to be responsible for its antibiotic activities, it reacts with cysteine and the reaction products are devoid of biological activities. Benesudon is the first secondary metabolite described from Mollisia benesuada, and its structure was determined by spectroscopic techniques.
从子囊菌贝内苏达莫利氏菌的深层培养物中分离出一种具有抗菌、抗真菌、细胞毒性和植物毒性活性的新型代谢产物——贝内苏酮。贝内苏酮含有一个反应性α-亚甲基酮基团，据信该基团是其抗生素活性的原因，它与半胱氨酸反应，反应产物没有生物活性。贝内苏酮是首次从贝内苏达莫利氏菌中描述的次生代谢产物，其结构通过光谱技术确定。
