巴西醌A、B和C，来自巴西诺卡氏菌的新型苯并[α]蒽醌类抗生素。I. 抗生素的产生菌株、分离及生物学活性

Brasiliquinones A, B and C, new benz[alpha]anthraquinone antibiotics from Nocardia brasiliensis. I. Producing strain, isolation and biological activities of the antibiotics.

作者信息

Nemoto A, Tanaka Y, Karasaki Y, Komaki H, Yazawa K, Mikami Y, Tojo T, Kadowaki K, Tsuda M, Kobayashi J

机构信息

Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.

出版信息

J Antibiot (Tokyo). 1997 Jan;50(1):18-21. doi: 10.7164/antibiotics.50.18.

DOI:10.7164/antibiotics.50.18

PMID:9066761

Abstract

New benz[alpha]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.

摘要

分离出了在C-3位带有一个乙基的新型苯并[α]蒽醌类抗生素（巴西醌A、B和C）。其产生菌被鉴定为巴西诺卡氏菌。这些抗生素对包括分枝杆菌属在内的革兰氏阳性菌有活性，但对革兰氏阴性菌或真菌无活性。它们对多重耐药的P388/ADR肿瘤细胞也有活性。