巴西诺内酯A，一种由巴西诺卡氏菌产生的新型大环内酯类抗生素：产生菌株、分离及生物活性

Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity.

作者信息

Tanaka Y, Komaki H, Yazawa K, Mikami Y, Nemoto A, Tojyo T, Kadowaki K, Shigemori H, Kobayashi J

机构信息

Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.

出版信息

J Antibiot (Tokyo). 1997 Dec;50(12):1036-41. doi: 10.7164/antibiotics.50.1036.

DOI:10.7164/antibiotics.50.1036

PMID:9510911

Abstract

A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was only active against Aspergillus niger, but not active against other fungi including yeasts as well as other filamentous like fungi and bacteria. Brasilinolide A exerted an immunosuppressive activity in the assay system of a mixed lymphocyte reaction (MLR).

摘要

一种新的32元大环内酯类抗生素——巴西内酯A，是从巴西诺卡氏菌IFM 0406的发酵液中分离得到的。该产生菌被鉴定为巴西诺卡氏菌。这种抗生素仅对黑曲霉有活性，而对包括酵母在内的其他真菌以及其他丝状真菌和细菌均无活性。在混合淋巴细胞反应（MLR）的检测系统中，巴西内酯A表现出免疫抑制活性。