Ash S, Scheman A J
Northwestern University, School of Medicine, Evanston, IL, USA.
Am J Contact Dermat. 1997 Mar;8(1):2-5.
Systemic contact dermatitis is an underreported type of delayed hypersensitivity caused by a systemically administered substance. When interpreting patch test reactions, it is important to obtain a history of all current related oral medications. Many oral medications can cross-react with structurally similar topical antigens and induce systemic contact dermatitis. Identification and elimination of the inciting agent can lead to resolution of otherwise chronic, unresponsive eczema. We report a case of systemic contact dermatitis to hydroxyzine in a patient who was patch tested positive to ethylenediamine. Repeated oral provocation with hydroxyzine reproduced her eczema on several occasions. We conclude that systemic contact dermatitis to hydroxyzine, a common medication used to treat pruritus, must be considered as a potential cause for unresponsive eczema.
系统性接触性皮炎是一种由全身给药的物质引起的、报告不足的迟发型超敏反应。在解释斑贴试验反应时，获取所有当前相关口服药物的病史很重要。许多口服药物可与结构相似的外用抗原发生交叉反应并诱发系统性接触性皮炎。识别并消除诱发因素可使原本慢性、无反应性的湿疹得到缓解。我们报告了一例对羟嗪发生系统性接触性皮炎的病例，该患者对乙二胺斑贴试验呈阳性。多次口服羟嗪激发试验使她的湿疹多次复发。我们得出结论，对于用于治疗瘙痒的常用药物羟嗪，必须将系统性接触性皮炎视为无反应性湿疹的潜在病因。
