Tomb R, Dolfus A, Couppie P
Hôpitaux Universitaires Strasbourg.
Ann Dermatol Venereol. 1992;119(10):761-4.
Skin irritation induced by tretinoin is commonly observed, whereas allergic contact dermatitis to this drug is very rarely found in the literature. We report the case of a 34-year-old man who developed contact dermatitis in areas where a topical tretinoin preparation was applied. Patch tests were positive to tretinoin in low concentration and to isotretinoin. Oral administration of isotretinoin to this patient would carry a risk of systemic complications.
维甲酸引起的皮肤刺激很常见，而文献中很少发现对这种药物的过敏性接触性皮炎。我们报告了一例34岁男性患者的病例，该患者在使用外用维甲酸制剂的部位出现了接触性皮炎。斑贴试验对低浓度维甲酸和异维甲酸呈阳性。对该患者口服异维甲酸会有发生全身并发症的风险。
