Rueda R, Garcia-Salmerón J L, Maldonado J, Gil A
Departamento de Investigación y Desarrollo, Abbott Laboratories, Granada, Spain.
Biol Chem. 1996 Sep;377(9):599-601.
We studied changes during lactation in the relative concentration of individual gangliosides in human milk from mothers delivering preterm and term infants. The relative content of G(D3) was higher in colostrum than in mature milk, and tended to be higher in preterm colostrum than in term colostrum, whereas the relative content of G(M3) was higher in mature milk than in colostrum, and was also higher in term than in preterm milk. As G(D3) is usually detected in developing tissues whereas G(M3) is more abundant in mature tissues, these results suggest a relationship between the presence of individual gangliosides in human milk and immaturity of the mammary gland in mothers of preterm infants.
我们研究了早产和足月分娩母亲的母乳中各神经节苷脂相对浓度在哺乳期的变化。初乳中G(D3)的相对含量高于成熟乳，早产初乳中的含量往往高于足月初乳，而G(M3)的相对含量在成熟乳中高于初乳，在足月母乳中也高于早产母乳。由于G(D3)通常在发育中的组织中被检测到，而G(M3)在成熟组织中更为丰富，这些结果表明，母乳中各神经节苷脂的存在与早产母亲乳腺的不成熟之间存在关联。
