Perelygin A A, Kammerer C M, Stowell N C, Rogers J
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
Cytogenet Cell Genet. 1996;75(4):207-9. doi: 10.1159/000134484.
A panel of 25 microsatellite loci known to map to human chromosome 18 was screened for length polymorphisms in a multigenerational pedigree of baboons (Papio hamadryas). Eight of these loci were polymorphic in the baboon pedigrees, with observed heterozygosity values ranging from 0.16 to 0.88. All eight loci show strong evidence of linkage. The most likely map order among the microsatellite loci for Papio is completely compatible with the locus order found in the human genome, and sex differences in recombination rates are also similar in the two species. We conclude that the organization of the chromosomal region defined by these loci is largely conserved between baboons and humans.
在一个多代狒狒（阿拉伯狒狒）家系中，对已知定位于人类18号染色体的25个微卫星位点进行了长度多态性筛选。其中8个位点在狒狒家系中具有多态性，观察到的杂合度值在0.16至0.88之间。所有8个位点都显示出强烈的连锁证据。狒狒微卫星位点之间最可能的图谱顺序与人类基因组中发现的位点顺序完全兼容，并且两个物种在重组率上的性别差异也相似。我们得出结论，由这些位点定义的染色体区域的组织在狒狒和人类之间基本保守。
