感染牛免疫缺陷病毒的犊牛的免疫抑制
Immune suppression in calves with bovine immunodeficiency virus.
作者信息
Zhang S, Wood C, Xue W, Krukenberg S M, Chen Q, Minocha H C
机构信息
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
出版信息
Clin Diagn Lab Immunol. 1997 Mar;4(2):232-5. doi: 10.1128/cdli.4.2.232-235.1997.
Abstract
The present study was designed to evaluate the effect of bovine immunodeficiency virus (BIV) infection on immune functions and possible interactions between BIV and other bovine viruses in calves. Ten calves were inoculated intravenously with BIV, and five served as controls. An increased lymphocyte proliferation to BIV gag protein was demonstrated 2 to 6 weeks after BIV inoculation (P < 0.05). Lymphocyte subset differentiation revealed a decreased CD4/CD8 ratio (P < 0.05) during weeks 2 to 7, suggesting a possible immune dysfunction in BIV-infected calves. When the calves were inoculated with bovine herpesvirus type 1 (BHV-1), the antibody response to BHV-1 in BIV-infected calves was delayed and the antibody titers were significantly lower (P < 0.05). Injection of bovine viral diarrhea virus vaccine also elicited a lower neutralizing antibody response in BIV-infected calves. The results indicated that immune suppression occurred in BIV-infected calves.
摘要
本研究旨在评估牛免疫缺陷病毒（BIV）感染对犊牛免疫功能的影响以及BIV与其他牛病毒之间可能的相互作用。10头犊牛经静脉接种BIV，5头作为对照。BIV接种后2至6周，显示出对BIV gag蛋白的淋巴细胞增殖增加（P < 0.05）。淋巴细胞亚群分化显示，在第2至7周期间CD4/CD8比值降低（P < 0.05），提示BIV感染的犊牛可能存在免疫功能障碍。当犊牛接种1型牛疱疹病毒（BHV-1）时，BIV感染的犊牛对BHV-1的抗体反应延迟，且抗体滴度显著较低（P < 0.05）。注射牛病毒性腹泻病毒疫苗在BIV感染的犊牛中也引发较低的中和抗体反应。结果表明，BIV感染的犊牛发生了免疫抑制。
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