Saraux A, Bendaoud B, Dueymes M, Le Goff P, Youinou P
Unit of Rheumatology, Brest University Medical School Hospital, France.
Ann Rheum Dis. 1997 Feb;56(2):126-9. doi: 10.1136/ard.56.2.126.
To determine the relevance of the functional affinity of IgM rheumatoid factor (RF) to the clinical and serological characteristics of patients with rheumatoid arthritis.
The functional affinity of IgM RF of 57 seropositive rheumatoid arthritis patients was evaluated by an enzyme linked immunosorbent assay based on the use of a chaotropic agent. The inhibition index was taken as an estimate of functional affinity. The patient group was divided into high functional affinity subgroup 1 (functional affinity < 0.5, n = 37) and low functional affinity subgroup 2 (functional affinity > 0.5, n = 20). The medical records of all patients were reviewed with a particular note of the disease activity and the articular damage score.
The disease duration was shorter (P < 0.01) in subgroup 1 patients [7.9 (SD 6.4) years] than in subgroup 2 patients [13.4 (11.29) years], so that Ritchie's, Lee's, and Steinbrocker's indices were lower in the former than in the latter (P < 0.01, 0.001, and 0.01, respectively). In contrast, erythrocyte sedimentation rates, C reactive protein concentrations, antinuclear antibody, and HLA DR4 prevalences were similar in the two subgroups.
Different forms of RF are present during progression of the disease.
确定IgM类风湿因子（RF）的功能亲和力与类风湿关节炎患者临床及血清学特征的相关性。
采用基于离液剂的酶联免疫吸附测定法评估57例血清阳性类风湿关节炎患者IgM RF的功能亲和力。抑制指数用作功能亲和力的评估指标。将患者组分为高功能亲和力亚组1（功能亲和力<0.5，n = 37）和低功能亲和力亚组2（功能亲和力>0.5，n = 20）。回顾了所有患者的病历，特别记录了疾病活动度和关节损伤评分。
亚组1患者[7.9（标准差6.4）年]的病程短于亚组2患者[13.4（11.29）年]（P < 0.01），因此前一组的里奇指数、李氏指数和斯坦布鲁克指数低于后一组（分别为P < 0.01、0.001和0.01）。相比之下，两组亚组的红细胞沉降率、C反应蛋白浓度、抗核抗体及HLA DR4患病率相似。
疾病进展过程中存在不同形式的RF。
