类风湿关节炎及其他自身免疫性疾病患者中IgM类风湿因子的功能亲和力
Functional affinity of IgM rheumatoid factor in patients with rheumatoid arthritis and other autoimmune diseases.
作者信息
Rath S, Hogben D N, Devey M E
机构信息
Department of Medical Microbiology, London School of Hygiene and Tropical Medicine, UK.
出版信息
Ann Rheum Dis. 1988 Apr;47(4):291-4. doi: 10.1136/ard.47.4.291.
The functional affinity of IgM rheumatoid factors (RF) was measured in 31 patients with rheumatoid arthritis (RA), 24 with systemic lupus erythematosus (SLE), 13 with Sjögren's syndrome (SS), and in 13 seropositive healthy individuals. The functional affinity of IgM RF from patients with RA was significantly lower than in the other clinical groups studied. In addition, there was a significant inverse correlation between functional affinity and titre of IgM RF in all the groups. These results suggest that the usual mechanisms of affinity based selective pressure (somatic diversification and antigen selection) may operate differently for autoantibodies to serum antigens such as IgG.
在31例类风湿关节炎（RA）患者、24例系统性红斑狼疮（SLE）患者、13例干燥综合征（SS）患者以及13例血清学阳性的健康个体中，检测了IgM类风湿因子（RF）的功能亲和力。类风湿关节炎患者的IgM RF功能亲和力显著低于其他所研究的临床组。此外，在所有组中，功能亲和力与IgM RF滴度之间存在显著的负相关。这些结果表明，基于亲和力的选择压力（体细胞多样化和抗原选择）的常见机制，对于针对血清抗原（如IgG）的自身抗体可能有不同的作用方式。
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